Studies published in the Journal of Infectious Diseases conducted during the 2017-2018 external icon and 2018-2019 external icon flu seasons among Medicare beneficiaries aged 65 years and older found that Fluzone High-Dose and FLUAD (a standard dose egg-based vaccine with MF 59 adjuvant approved for people 65 years and older) provided greater protection against flu-related hospitalizations than standard-dose, egg based vaccines in both seasons. Does Fluzone High-Dose Quadrivalent offer better protection than the adjuvanted flu vaccine? Data comparing the effectiveness of Fluzone High-Dose Quadrivalent with standard-dose inactivated quadrivalent vaccines are not yet available. This study was conducted during the 2013-14 flu season among more than 38,000 resident of 823 nursing homes in 38 states.įor the 2021-22 season, all Fluzone High-Dose vaccine will be quadrivalent. Another study published in The Lancet Respiratory Medicine external icon reported that people 65 years and older who got Fluzone High-dose had a lower risk of hospital admission compared with people in that age group who got the standard-dose Fluzone, especially those living in long-term care facilities. A study published in the New England Journal of Medicine external icon indicated that the high-dose vaccine was 24% more effective in preventing flu in adults 65 years and older relative to a standard-dose vaccine. Are there benefits of Fluzone High-Dose Quadrivalent compared to standard dose seasonal flu vaccines for adults 65 years and older?ĭata from clinical trials comparing Fluzone (a trivalent standard dose vaccine) to Fluzone High-Dose (a previously available trivalent high-dose vaccine) among people 65 years and older indicated that a stronger immune response (i.e., higher antibody levels) occured after vaccination with Fluzone High-Dose. There are a number of other flu vaccines produced by other manufacturers. Both Fluzone High-Dose and Fluzone Quadrivalent (standard dose) are produced by the same manufacturer and are quadrivalent vaccines. The higher dose of antigen in the vaccine is intended to give people 65 years and older a better immune response to vaccination, and therefore, better protection against flu. What is the difference between Fluzone High-Dose Quadrivalent and Fluzone Quadrivalent?įluzone High-Dose Quadrivalent contains four times the antigen, the part of the vaccine that helps your body build up protection against flu viruses, than Fluzone Quadrivalent and other standard-dose inactivated flu vaccines. Information about vaccine ingredients is located in package inserts from each manufacturer. Fluzone High-Dose Quadrivalent is not recommended for people with a history of severe allergic reaction to the vaccine or to ingredients other than eggs. In the United States, Fluzone High-Dose Quadrivalent is licensed only for people 65 years and older. Who can receive Fluzone High-Dose Quadrivalent? Fluzone High-Dose Quadrivalent is a four-component (quadrivalent) flu vaccine approved for people 65 years and older. What is Fluzone High-Dose Quadrivalent vaccine?įluzone High-Dose Quadrivalent is the only licensed high-dose inactivated influenza (flu) vaccine it is manufactured by Sanofi Pasteur Inc. This page provides information on the high-dose seasonal flu vaccine, Fluzone High-Dose Quadrivalent external icon. Why is there a need for flu vaccines designed specifically for people 65 years and older?.What other flu vaccines are available for people 65 years and older?.Where can I find more information about Fluzone High-Dose Quadrivalent?.Does CDC recommend one vaccine above another for people 65 years and older?.How safe is Fluzone High-Dose Quadrivalent?.Does Fluzone High-Dose Quadrivalent offer better protection than the adjuvanted flu vaccine?.Are there benefits of Fluzone High-Dose Quadrivalent compared to standard dose seasonal flu vaccines for adults 65 years and older?.
Who can receive Fluzone High-Dose Quadrivalent?.What is Fluzone High-Dose Quadrivalent vaccine?.
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